Biochemistry & Pharmacology: Open Access
Open Access
ISSN: 2167-0501
+44-20-4587-4809
ISSN: 2167-0501
+44-20-4587-4809
Regina Helena Silva
Departamento de Farmacologia – UNIFESP,
Rua Botucatu, 862, Edifício Leal Prado, 1º.andar, CEP 04023062 - São Paulo, SP
Brazil
Research Article
Alpha-Tocopherol Counteracts Cognitive and Motor Deficits Induced by Repeated Treatment with Reserpine
Author(s): Aldair José Sarmento-Silva, Ramón Hypolito Lima, Alicia Cabral, Ywlliane Meurer, Alessandra Mussi Ribeiro and Regina Helena SilvaAldair José Sarmento-Silva, Ramón Hypolito Lima, Alicia Cabral, Ywlliane Meurer, Alessandra Mussi Ribeiro and Regina Helena Silva
Previous studies showed that chronic administration of the monoamine depleting agent reserpine in low doses promotes progressive cognitive and motor impairments in rats, and this protocol has been used as a pharmacological progressive model of Parkinson's disease. These behavioral alterations are accompanied by increased brain oxidative stress. We aimed to verify the effects of the concomitant treatment with the antioxidant agent alpha-tocopherol on the motor and cognitive deficits induced by chronic reserpine in rats. Rats were repeatedly treated with 0.1 mg/kg reserpine with or without a concomitant treatment with 40 mg/kg alpha-tocopherol. Across the treatment, motor and cognitive performances were evaluated by the catalepsy and novel object recognition tests, respectively. As expected, reserpinetreated rats showed progressively increased duration of catalepsy together with sho.. View More»
DOI:
10.4172/2167-0501.1000153