Biochemistry & Pharmacology: Open Access

Biochemistry & Pharmacology: Open Access
Open Access

ISSN: 2167-0501

Quan Jiang

Quan Jiang
Key Laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, 610065,

  • Research Article
    Adrenergic Regulation of Somatolactin Gene Expression in Tilapia Pituitary Cells
    Author(s): Quan Jiang, Tianqiang Liu and Anji LianQuan Jiang, Tianqiang Liu and Anji Lian

    Epinephrine is an important neuroendocrine regulator to control growth hormone (GH) secretion in vertebrates. Somatolactin (SL), the latest member of the GH family, is a novel pituitary hormone with diverse functions in fish. In a previous report it was shown that epinephrine had a potent inhibitory effect on SL release in fish. However, very little is known about the mechanisms responsible for epinephrine inhibition of SL gene expression. In primary cultures of tilapia neurointermediate lobe (NIL) cells, epinephrine not only reduced SL mRNA levels, but could also abolish pituitary adenylate cyclase-activating polypeptide (PACAP)-stimulated SL gene expression. The inhibitory effects of epinephrine on SL gene expression were mimicked by additions of α2-adrenergic agonists clonidine and UK14304, whereas similar treatments with the α1-agonist cira.. View More»
    DOI: 10.4172/2167-0501.1000203

    Abstract PDF

Relevant Topics