Gynecology & Obstetrics
Open Access
ISSN: 2161-0932
ISSN: 2161-0932
Qingzheng Chen
Tanzania
Review Article
Involvement of the Bufodienolides in the Pathogenesis and Potential Therapy of Preeclampsia, the Acute Respiratory Distress Syndrome and Traumatic Brain Injury
Author(s): Qingzheng Chen, Kamran Abbas, Muppala Raju and Jules B. PuschettQingzheng Chen, Kamran Abbas, Muppala Raju and Jules B. Puschett
The purpose of this review is to provide detailed information on the evidence for marinobufagenin (MBG) as a predictive and causative factor in preeclampsia(PE), the acute respiratory distress syndrome(ARDS) and traumatic brain injury (TBI). In addition, evidence is provided that resibufogenin (RBG),the antagonist of MBG is effective in the treatment of all three diseases. Results from experiments conducted on animal models and in human subjects indicate that patients with PE, ARDS and TBI have increased urinary and serum MBG levels. In PE patients, MBG is elevated in the early stages of pregnancy. In ARDS, MBG was elevated in serum samples of hyperoxic rats. MBG levels were also elevated in concussed athletes and in rat studies in which TBI was induced. In the animal models, all three disease processes were prevented/treated by the administration of RBG. Human trials of MBG as a pred.. View More»
DOI:
10.4172/2161-0932.1000460