Biochemistry & Pharmacology: Open Access
Open Access
ISSN: 2167-0501
+44-20-4587-4809
ISSN: 2167-0501
+44-20-4587-4809
Paul C. Chikezie
Owerri
Nigeria
Research Article
Changes in Hepato-Renal Tissues Biomarkers of Alloxan-Induced Diabetic Wistar Rats Co-Administered Monosodium Glutamate and Ascorbic Acid
Author(s): Paul C. Chikezie, Blessing Chinonso Ezeocha and Promise NwankpaPaul C. Chikezie, Blessing Chinonso Ezeocha and Promise Nwankpa
The present study investigated the capacity of combined administration of monosodium glutamate (MSG) and ascorbic acid to reverse altered hepatorenal functions in Type 1 diabetes mellitus (DM) Wistar rats. Single intra-peritoneal (i.p.) injection of 90 mg/kg body weight (b.w.) of alloxan monohydrate in phosphate buffered saline (pH=7.4) was used to induce DM in the rats. Standard spectrophotometric methods were used to measure hepatorenal biomarkers; namely, serum alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) activities as well as serum total bilirubin, urea and creatinine concentrations. Serum ratios of ALT to AST activities of the experimental rat groups were greater than 1 unit and within the range of 1.26 - 2.69 units. Serum ALP activities of the experimental rat groups were within the range of 84.08 ± 12.73 - 393.33 ± 35.67 .. View More»
DOI:
10.4172/2167-0501.1000251