Anatomy & Physiology: Current Research
Open Access
ISSN: 2161-0940
+44 1300 500008
ISSN: 2161-0940
+44 1300 500008
Paola Valdivieso
Switzerland
Research Article
Gene-Pharmacologial Effects on Exercise-Induced Muscle Gene Expression in Healthy Men
Author(s): Sebastian Mathes, Sander van Ginkel, David Vaughan, Paola Valdivieso and Martin FlückSebastian Mathes, Sander van Ginkel, David Vaughan, Paola Valdivieso and Martin Flück
Angiotensin 2 is a major vasoconstrictor and subject to complex regulation. It is produced by the angiotensinconverting enzyme (ACE), which is itself regulated by blood flow and represents a target for pharmacological (lisinopril) and genetical (ACE-I/D polymorphism) influences. 32 healthy Caucasian men of British descent, including six subjects that were treated with lisinopril, completed standardized one-legged cycling-type endurance exercise to assess ACE-I/D and lisinopril dependent levels alterations of ACE and hypoxia-modulated transcripts in knee extensor muscle. Lisinopril treatment revealed significantly decreased transcript expression at baseline (COX4I1-88%; COX4I2 -67%; HIF-1α -93%) and 3 hours into recovery (HIF-1α -78%; ACE -62%). Furthermore, during recovery from cycling-type endurance exercise, COX4I2 mRNA expression was increased by 281% in ACE-II genotype.. View More»
DOI:
10.4172/2161-0940.S5-005