Biochemistry & Pharmacology: Open Access
Open Access
ISSN: 2167-0501
+44-20-4587-4809
ISSN: 2167-0501
+44-20-4587-4809
Omale James
Faculty of Natural Sciences, Department of Biochemistry,
P.M.B. 1008, Anyigba, Kogi State
Nigeria
Research Article
Wound Healing and Anti-Ulcerogenic Activity of Gardenia angustifolia Extract in Rats
Author(s): Omale James, Abbah Okpachi Christopher, Ojogbane Eleojo Berikisu, David Ede Patience and Adah Gabriel OnucheOmale James, Abbah Okpachi Christopher, Ojogbane Eleojo Berikisu, David Ede Patience and Adah Gabriel Onuche
Gardenia angustifolia is widely utilized in many parts of Nigeria to manage a wide range of ailments. As part of effort to elucidate its pharmacological activities and hence medicinal potential, wound healing and anti-ulcerogenic properties of the extract was evaluated using experimentally created wound and ulcers in albino rats. Wound healing properties was evaluated using excision wound model, while anti-ulcer activity was studied using ethanol induced ulcer model. Five groups of rats were experimentally wounded at the back area. An area of uniform wound of 7×7 mm using millimeter ruler was excised. The animal groups were topically treated with Gardenia angustifolia gel, wound dressed with leaf, fruit and root gel significantly healed earlier than those treated with paraffin base and povidone iodine (standard). In anti-ulcer studies, rats were orally administered with differen.. View More»
DOI:
10.4172/2167-0501.1000112