Anatomy & Physiology: Current Research

Anatomy & Physiology: Current Research
Open Access

ISSN: 2161-0940

Odigie OM

Odigie OM
Faculty of Basic Medical Sciences, College of Health Sciences,
Abraka, Delta State

  • Research Article
    Mitigations in Selected Haemostatic Parameters in Administration of Graded Doses of Dexamethasone and its Blockers in Wister Rats
    Author(s): Nwangwa EK and Odigie OMNwangwa EK and Odigie OM

    Clinical trials have shown that an even newer compound, dexamethasone (Dex), might be more potent and less likely to cause side-effects than any other known corticosteroid medication. This study investigated the possible changes in selected haemostatic parameters [clotting time, bleeding time, platelets count and fibrinogen level] in albino wistar rats, following administration of graded doses of Dex. Forty-two male albino Wistar rats were randomly grouped into seven of six rats each. With Group A receiving normal diets (Control), Groups B-G were respectively given 0.1 mg/Kg of Dex, 0.3 mg/Kg of Dex, 0.1 mg/Kg of Dex +33 mg/Kg of Ketokonazol (Keto), 0.3 mg/Kg of Dex +33 mg/Kg of Keto, 0.1 mg/Kg of Dex+Vitamin (Vit) E and 0.1 mg/Kg of Dex. +Vit E. following two-weeks administration period, rats were euthanized and blood samples obtained by cardiac puncture under diethyl ether to determ.. Read More»
    DOI: 10.4172/2161-0940.1000297

    Abstract PDF

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