Biochemistry & Pharmacology: Open Access
Open Access
ISSN: 2167-0501
+44-20-4587-4809
ISSN: 2167-0501
+44-20-4587-4809
Noura M Darwish
Alexandria
Egypt
Research Article
The Role of Novel 3d-Copper Cyanide Supramolecular Coordination Polymer in Epithelial Mesenchymal Transition Inhibition in Hepatocellular Carcinoma
Author(s): Noura M Darwish, Fahad A Al-Dhabaan, Ahmed Sultan, Ahmed Malki and Mohamed Soliman ElshikhNoura M Darwish, Fahad A Al-Dhabaan, Ahmed Sultan, Ahmed Malki and Mohamed Soliman Elshikh
Background: Aberrant activation of the Ras/Raf-1/extracellular-regulated kinase (ERK) pathway has been shown to be involved in the progression of hepatocellular carcinoma (HCC). However, the mechanism of dysregulation of ERK activation is poorly understood. This study aimed to investigate the inhibitory effect of novel 3D-organocopper supramolecular coordination polymer (SCP) on invasive potential of hepatocellular carcinoma (HCC) cells and to explore the underlying mechanism. Chemoprevention could represent an important means to inhibit the process of hepatocarcinogenesis.
Methods: The inhibitory effect of SCP compound on hepatoma cells was evaluated by the examination of HCC chemically induced liver tissues and specific pathway inhibition was examined by immunohistochemistry.
Results: Recently, we identified the newly .. View More»
DOI:
10.4172/2167-0501.1000233