Biochemistry & Pharmacology: Open Access

Biochemistry & Pharmacology: Open Access
Open Access

ISSN: 2167-0501

Nachum Dafny

Nachum Dafny
Medical School at Houston 6431 Fannin St. MSB 7.208B, Houston, Texas 77030,

  • Research Article
    Does Methylphenidate (MPD) Have the Potential to Become Drug of Abuse?
    Author(s): Nachum DafnyNachum Dafny

    The psychostimulant methylphenidate (MPD) is the pharmacotherapy of choice for the treatment of attention deficit disorder (ADD), attention deficit hyperactivity disorder (ADHD), narcolepsy, dementia, chronic fatigue and useful in providing relief from intractable pain. More recently students of all ages use MPD (Ritalin) as a cognitive enhancement to help them study and perform better during exams. Many of them abuse the drug for recreation. This chapter aims to provide a short review of the pharmacological property of MPD. MPD can elicit behavioral sensitization or tolerance – behavioral sensitization and tolerance are experimental markers indicating dependence. Some behavior experiments using an MPD dose response protocol demonstrated that MPD elicits behavioral sensitization and other studies reported behavioral tolerance. Our dose response study of chronic MPD dose response.. Read More»
    DOI: 10.4172/2167-0501.1000156

    Abstract PDF

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