Biochemistry & Pharmacology: Open Access

Biochemistry & Pharmacology: Open Access
Open Access

ISSN: 2167-0501


Muthu K

Muthu K


  • Research Article
    Effect of Vitamin C and Vitamin E on Mercuric Chloride-Induced Reproductive Toxicity in Male Rats
    Author(s): Muthu K and Krishnamoorthy PMuthu K and Krishnamoorthy P

    To evaluate the protective effects of Vitamin C and Vitamin E against Mercuric chloride -induced reproductive toxicity and to study the mechanisms underlying these effects. Male Wistar rats were orally administered mercuric chloride (10 mg/100 gm b.wt), (10 mg/100 gm b.wt) of mercuric chloride + (40 mg/100 gm b.wt) of Vitamin C and (10 mg/100 gm b.wt) of mercuric chloride + (20 mg/100 gm b.wt) of Vitamin E were administered orally to male albino rats for 30 days. Treatments with either Vitamin C or Vitamin E resulted in a significant protection of reproductive function. Both vitamins reduced the extent of mercuric chloride-induced reproductive toxicity, as evidenced by decrease in sperm abnormality and increase in sperm motility. Mercuric chloride-induced alterations in testis lipid peroxidation (MDA) were also markedly improved by test vitamins, and mercuric chloride -induced alterat.. View More»
    DOI: 10.4172/2167-0501.1000102

    Abstract PDF

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