Gynecology & Obstetrics
Open Access
ISSN: 2161-0932
ISSN: 2161-0932
Mohammad M Yousef
Saudi Arabia
Case Report
Metachronous Multifocal Osseous Rosai-Dorfman Disease in a Pregnant Woman: Report of an Unusual Case and Brief Review of Pertinent Literature
Author(s): Marwah M Abdulkader, Samir S Amr, Mohammad M Yousef, Hesham A Musleh, Amani A Joudeh, Mohammad H Nahhas and Mousa A Al-AbbadiMarwah M Abdulkader, Samir S Amr, Mohammad M Yousef, Hesham A Musleh, Amani A Joudeh, Mohammad H Nahhas and Mousa A Al-Abbadi
Rosai-Dorfman disease (RDD) is a rare histiocytosis that most commonly involves the cervical lymph nodes. Extranodal involvement occurs in 30-40% of cases and most often in the head and neck region. Prognosis is generally excellent. We present an unusual case of metachronous Rosai-Dorfman disease arising in multifocal bone sites in a 25-year-old pregnant female. She presented with right shoulder pain, frontal headache associated with fever and sweating. Computed Tomography scan and Magnetic Resonance Imaging studies demonstrated well-circumscribed lesions in the proximal humerus followed by a similar lesion in the frontal bone of the skull. Microscopic examination revealed variable numbers of pale-staining histiocytes with emperipolesis and background lymphoplasmacytic infiltrate and fibrosis. Immunohistochemical studies revealed positive staining of these histiocytes for S100 and CD6.. View More»
DOI:
10.4172/2161-0932.1000198