Endocrinology & Metabolic Syndrome
Open Access
ISSN: 2161-1017
+44 1478 350008
ISSN: 2161-1017
+44 1478 350008
Mittre H
University of Caen Lower Normandy, EA 2608 laboratory; Caen University Hospital,
Department of Genetics, Caen, 14000
France
Rapid Communication
ESR1 and FSHR Gene Polymorphisms Influence Ovarian Response to FSH in Poor Responder Women with Normal FSH Levels
Author(s): Rod A, Jarzabek K, Wolczynski S, Benhaim A, Reznik Y, Denoual-Ziad C, Herlicoviez M and Mittre HRod A, Jarzabek K, Wolczynski S, Benhaim A, Reznik Y, Denoual-Ziad C, Herlicoviez M and Mittre H
In COS (Controlled Ovarian Stimulation), individual response are highly variable. A number of studies have evaluated the ovarian response to FSH in women most often aged over 35 years and with high FSH level. But we see also a poor response to ovarian stimulation in young women (<32 years) with normal FSH levels.The aim of this study was to evaluate the relationship between FSHR and ESR1 gene polymorphism in this young women population.
For 70 patients, the FSHR p.Ala307Thr (rs6165) and p.Ser680Asn (rs6166) single-nucleotide polymorphisms (SNPs), the ESR1 PvuII T/C (rs2234693) SNP, and the (TA)n microsatellite polymorphism were studied alone or in combination. We found that the frequency of the p.307[Ala;Ala] FHSR genotype was 3-fold higher in poor responders (PRs) to COS (Controlled Ovarian Stimulation) than in good responders (GRs).The frequency of ESR1 polymorphism was n.. View More»
DOI:
10.4172/2161-1017.1000141