Biochemistry & Pharmacology: Open Access

Biochemistry & Pharmacology: Open Access
Open Access

ISSN: 2167-0501


Ming Gao

Ming Gao
Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center,
Phoenix, AZ 85013-4496

  • Review Article
    The Roles of a5-Containing nAChRs in the Brain
    Author(s): Ming Gao, Yakun Wang and Jie WuMing Gao, Yakun Wang and Jie Wu

    Neuronal nicotinic acetylcholine receptors (nAChRs) are in the superfamily of the ligand-gated ion channels with an assembly of five subunits (a, bī€ subunit). nAChRs, such as a4b-and a7-nAChRs play crucial roles in nicotine reward, dependence and withdrawal. Recently, functional profiles of the a5 nAChRs have been studied using the a5 knockout (KO) and the overexpression mice. a5-nAChRs in the brain participate in neuronal activities associate with nicotine dependence, withdrawal, aversion, as well as alcohol use disorders. The main focus of this review is to underst and a5-containing nAChR’s properties, function, and related disorders recently discovered. .. View More»
    DOI: 10.4172/2167-0501.1000129

    Abstract PDF

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