Michael Laffin
Canada
Review Article
Colorectal Adenocarcinoma and Inflammatory Bowel Disease: An Update and Review
Author(s): Michael Laffin and Shahzeer KarmaliMichael Laffin and Shahzeer Karmali
Inflammatory bowel disease and its two prototypic illnesses: Crohn’s disease and ulcerative colitis have long been thought to confer an increased risk of colorectal cancer, although the magnitude of this effect has been difficult to elucidate. The driving factors behind this relationship include genetics, microbial disturbances, alongside molecular and inflammatory misregulation. The epidemiologic understanding of the inflammatory bowel disease-colorectal cancer relationship has evolved over the last decade. This review will focus on the epidemiology of colorectal cancer in inflammatory bowel disease, and detail the elements driving disease development. Patient risk factors, many that increase the intensity or duration of inflammation, will be detailed. Finally, a practical approach to the tools that clinicians have at their disposal in preventing th.. View More»
