Gynecology & Obstetrics
Open Access
ISSN: 2161-0932
ISSN: 2161-0932
Martinez S
Spain
Research Article
Three-Dimensional Angiogenic Evaluation of the Effect of Mifepristone in Early Gestation: Pilot Study
Author(s): Pellicer-Iborra B, Herraiz S, Morales A, Martinez S, Garrido N and Pellicer APellicer-Iborra B, Herraiz S, Morales A, Martinez S, Garrido N and Pellicer A
Mifepristone (RU486) it is known as an effective abortifacient and postcoital contraceptive method, whose mechanism is not yet known. We carried on a pilot study with the aim of determining the effect that Mifepristone could have in utero-placental vascular compartment during the first trimester of pregnancy compared with placebo. This is a randomized, double-blind, placebo-controlled research. We randomly assigned to two groups patients requesting pregnancy termination with a gestational age between 9th and 11st weeks: Group A receiving placebo and Group B receiving RU. With transvaginal ultrasound tridimensional probe we measured at an initial time (t1) and then 4 hours after administration of Mifepristone or placebo (t2) Doppler parameters: uterine arteries mean Resistance Index, spiral arteries Resistance Index, intervillous flow, umbilical Resistance Index a.. View More»
DOI:
10.4172/2161-0932.1000451