Journal of Pharmaceutical Care & Health Systems
Open Access

Maria José Morsoleto

Publications

• Research Article
  Salivary Glands of Female Ticks Rhipicephalus sanguineus Like a Potential Source of Molecules with Inhibitory Action: In vivo study with Walker 256 Tumor Cells
  Author(s): Marina Rodrigues de Abreu, Fabiana Alonso Rocha, Karim C. S. Furquim, Luis Adriano Anholeto, Fabiana Cristina Fuzaro Novaes, Maria José Morsoleto and Maria Izabel Camargo-MathiasMarina Rodrigues de Abreu, Fabiana Alonso Rocha, Karim C. S. Furquim, Luis Adriano Anholeto, Fabiana Cristina Fuzaro Novaes, Maria José Morsoleto and Maria Izabel Camargo-Mathias
  
  This study evaluated the effects of one or two injection of differents concentrations (0.2 and 0.04μg/μL) of extracts obtained from the salivary glands of female ticks Rhipicephalus sanguineus (Acari: Ixodidae) (Latreille, 1806) also called “brown dog tick” fed for 2 days on the rabbit hosts on the morpho-physiology of the leg musculature of female Wistar rats inoculated with Walker 256 tumor cells. The number of leukocytes and the creatinine levels were quantified for individuals from all groups. The results of both histology and electron microscopy revealed that a single, low-concentration injection of the extract (0.04μg/μL) was more effective in containing tumor invasion and caused less ‘collateral damage’ to the muscle tissue, which was the object of this study. The results also revealed that creatinine levels were higher in rats subjected to b.. View More»
  DOI: 10.4172/2376-0419.1000121

  Abstract PDF

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