Biochemistry & Pharmacology: Open Access
Open Access
ISSN: 2167-0501
+44-20-4587-4809
ISSN: 2167-0501
+44-20-4587-4809
Magdalena Sastre
Imperial College London, Hammersmith Hospital,
Du Cane Road, London W12 0NN
United Kingdom
Research Article
Alterations in the Expression of Transcription Factors PPARγ and NFκB in the Brain of Models of Chronic Pain
Author(s): Amy M Birch, Jonathan Cheung, Christianah Oluwadare, James Burton, Wenlong Huang, Amparo Novejarque, Julia Inglis and Magdalena SastreAmy M Birch, Jonathan Cheung, Christianah Oluwadare, James Burton, Wenlong Huang, Amparo Novejarque, Julia Inglis and Magdalena Sastre
Recent evidence has highlighted the role of nuclear receptors Peroxisome Proliferator-Activated Receptor (PPAR) α and PPARγ in the neuroinflammatory state associated with acute inflammatory and neuropathic pain. Its relevance in the control and treatment of pain has been confirmed by the beneficial effects of treatment with Thiazolidinediones and fibrates. The aim of this study was to evaluate the expression of PPARα, PPARγ, and Nuclear Factor kappa B (NFκB) in the brains of rodent models of inflammatory pain, peripheral neuropathy and peripheral nerve injury, including the collagen induced arthritis (CIA), Spinal Nerve Transection (SNT) and Anti-Retroviral (ART) models. Our results reveal that PPARγ levels are generally reduced in models of persistent pain, while NFκB expression is upregulated, with no major changes in PPARα expression. Th.. View More»
DOI:
10.4172/2167-0501.1000217