Biochemistry & Pharmacology: Open Access

Biochemistry & Pharmacology: Open Access
Open Access

ISSN: 2167-0501

Lin Guo

Lin Guo


  • Review Article
    The Extracellular α-Synuclein and its Biological Significance
    Author(s): Lin Guo and Xuechu ZhenLin Guo and Xuechu Zhen

    α-synuclein plays an important role in the development of Parkinson’s disease (PD). It was believed that α-synuclein elicits its effects in the neuronal cytosol. However, the finding of extracellular α-synuclein expands the orthodox spectrum. The α-synuclein can be secreted via the multi-vesicle bodies-mediated exosome and the recycling-endosome pathway. In the intercellular milieu, the secreted α-synuclein is degraded by enzymes or engulfed by neighboring cells. The remaining α-synuclein can induce the neurotoxicity, activate microglia, and promote the pathogenesis of Parkinson’s disease. In the review, we focus on the recent findings of extracellular α-synuclein and its biological significance. .. View More»
    DOI: 10.4172/2167-0501.S1-001

    Abstract PDF

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