Biochemistry & Pharmacology: Open Access
Open Access
ISSN: 2167-0501
+44-20-4587-4809
ISSN: 2167-0501
+44-20-4587-4809
Li Han
Nippon Suisan Kaisha, Ltd.,
Tokyo
Japan
Research Article
Oral Intake of Krill Oil Has Prophylactic and Potential Therapeutic Effects on Alcoholic Fatty Liver in Rats Fed With High-Fat Diet
Author(s): Hong-ling Wang, Mao-wu Guo, Qin Liao, Hui Wang, Wei-juan Zhang, Yun-xia Sun, Li Han, Tomoko Tsuji and Conglin ZuoHong-ling Wang, Mao-wu Guo, Qin Liao, Hui Wang, Wei-juan Zhang, Yun-xia Sun, Li Han, Tomoko Tsuji and Conglin Zuo
Aim: The objective of this study was to evaluate the prophylactic and therapeutic effects of Krill Oil on alcohol induced fatty liver in rats on high-fat diet. Methods: Male Sprague-Dawley rats (7-8 weeks old) were gavaged with alcohol and fed with high-fat diet for six weeks to induce alcoholic fatty liver. The concentration of the alcohol formulation had a step increase to have the animal acclimated, with 8% in week 1, 12% in week 2, 20% in week 3, 30% in week 4, and 40% alcohol in the following weeks, and the dose volume was 10 ml/kg. Krill oil at daily oral dose of 10, 100 or 1000 mg/kg was given to animals along with alcohol gavage in a prophylactic experiment, or at 100 and 1000 mg/kg after six weeks of alcohol gavage in a therapeutic experiment, with or without continuing oral gavage of alcohol for four weeks. Blood samples and liver tissues were ta.. View More»
DOI:
10.4172/2167-0501.1000189