Biochemistry & Pharmacology: Open Access
Open Access

Koch M

Publications

• Research Article
  Acute Co-Administration of the Cannabinoid Receptor Agonist WIN 55- 212,2 does not Influence 3,4-Methylenedioxymetamphetamine (MDMA)- Induced Effects on Effort-Based Decision Making, Locomotion, Food Intake and Body Temperature
  Author(s): Schulz S, Gundelach J, Hayn L, Koch M and Svärd HKSchulz S, Gundelach J, Hayn L, Koch M and Svärd HK
  
  Acute behavioural effects of co-administration of the illegal drug 3,4-methylenedioxymethamphetamine (MDMA, 7.5.mg/kg, s.c.) and the synthetic cannabinoid receptor agonist WIN55212-2 (WIN, 1.2mg/kg, i.p.) in rats were investigated. MDMA impaired performance on a T-maze effort-based decision making task. MDMA and MDMA+WIN treatment increased body temperature to a similar extent, whereas WIN increased temperature at an earlier time point. Locomotion, exploratory behaviour and food intake was comparable in MDMA and MDMA+WIN-treated animals. MDMAinduced decreased exploration anxiety in the open field was diminished by WIN. In summary, acute co-administration of the cannabinoid receptor agonist did not substantially modulate the MDMA-induced behavioural effects. .. View More»
  DOI: 10.4172/2167-0501.1000127

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