Biochemistry & Pharmacology: Open Access
Open Access
ISSN: 2167-0501
+44-20-4587-4809
ISSN: 2167-0501
+44-20-4587-4809
Kamel Rouissi
Laboratory of Genetics Immunology, and Human Pathology, Faculty of sciences of Tunis, University of El Manar I,
2092, Tunis
Tunisia
Research Article
Therapeutic Effects of Aloe Vera Plant Extract Against Cyclophosphamide and Buthionine Sulfoximine Induced Toxicities in the Bladder
Author(s): Kamel Rouissi, Soumaya Kouidhi, Bechr Hamrita, Slah Ouerhani, Mohamed Cherif and Amel Benammar ElgaaiedKamel Rouissi, Soumaya Kouidhi, Bechr Hamrita, Slah Ouerhani, Mohamed Cherif and Amel Benammar Elgaaied
Bladder toxicity is one of the most troublesome side effects associated with chemotherapeutic treatments of cancer involving the use of cyclophosphamide (CP) and buthionine-SR-sulfoximine (BSO). The present study was undertaken to investigate the effects of pre-treatment with an Aloe vera plant extract (AVE) on the urotoxicity induced by acute doses of CP and BSO using a Swiss albino mice model. The modulation of toxicity was evaluated by measuring lipid peroxidation (LPO), peroxide hydrogen production (H2O2) and antioxidants in the urinary bladder of the animals. The findings revealed that Aloe vera induced remarkable protective effects in terms of both LPO and enzymatic antioxidant activities. The CP-treated mice were noted to undergo significant decreases in the activities of glutathione S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GP), and catalase (CAT.. View More»
DOI:
10.4172/2167-0501.1000101