Biochemistry & Pharmacology: Open Access
Open Access
ISSN: 2167-0501
ISSN: 2167-0501
Jong-Sup Bae
College of Pharmacy, Research Institute of Pharmaceutical Sciences, School of Medicine,
80 Daehak-ro, Buk-gu, Daegu 702-701
Republic of Korea
Editorial
Potential Herbal Therapy of HMGB1-Targeting Agent in Sepsis
Author(s): Wonhwa Lee and Jong-Sup BaeWonhwa Lee and Jong-Sup Bae
High Mobility Group Box 1 (HMGB1) is highly conserved through evolution, and has 99% identity among all mammals. Out of its 215 amino acids, only two residues are substituted in the rodent and human versions. HMGB1 was originally described as a nuclear protein that binds DNA, and functions as a co-factor that is required for transcriptional regulation and gene expression. .. View More»
DOI:
10.4172/2167-0501.1000e129