Endocrinology & Metabolic Syndrome
Open Access
ISSN: 2161-1017
+44 1478 350008
ISSN: 2161-1017
+44 1478 350008
John P. Thyfault
Colombia
Review Article
Weight loss-induced increases in osteocalcin are associated with improvements in glucose homeostasis
Author(s): Pamela S. Hinton, John P. Thyfault, Tom R. Thomas, Bryan K. Smith, Joseph E. Donnelly and R. Scott RectorPamela S. Hinton, John P. Thyfault, Tom R. Thomas, Bryan K. Smith, Joseph E. Donnelly and R. Scott Rector
Background: Recent data suggest that the weight loss-associated increase in the osteoblast-specific peptide osteocalcin (OC) might be related, not to increased bone formation, but to the endocrine action of OC enhance to both pancreatic insulin secretion and insulin sensitivity of target tissues. Thus, the purpose of the present study was to examine the possible role of serum OC as a regulator of glucose homeostasis following weight loss in sedentary overweight or obese women.
Methods: This study was a post hoc analysis of three independent weight-loss intervention studies, which varied in weight-loss magnitude and duration. Serum glucose, insulin, bone formation (OC and bone-specific alkaline phosphatase, BAP) and resorption (C-terminal peptide of type I collagen, CTX) markers were measured before and after weight loss in sedentary overweight.. View More»
DOI:
10.4172/2161-1017.S1-002