Biochemistry & Pharmacology: Open Access
Open Access

Jiapu Zhang

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• Editorial
  A Survey on π-π Stackings and π-Cations in Prion Protein Structures
  Author(s): Jiapu ZhangJiapu Zhang
  
  π-π stackings and π-cations clearly do some contributions to maintain the structural stability of a normal cellular prion protein (PrP). This short article is to do a survey on the π-π stackings and π-cations in all the PrP structures listed in the PDB (www.rcsb.org) Bank. We find the following important π-π stackings: Y218–F175– Y169 (around the β2-α2 loop), Y162–Y128 (linking the two β-strands), F141–Y150– Y157 (in α-helix 1), H187–F198 (linking α-helix 2 and the α2-α3 loop); and we also find the following important π-cations: F141–R208.(N)NH2 (linking the β1-α1 loop and α- helix 3), Y128–R164.(N)NH2–Y169 (linking β-strand 1 and the β2-α2 loop). Thus, for PrPs, there exists a long “π-chain&rdqu.. View More»
  DOI: 10.4172/2167-0501.1000e175

  Abstract PDF

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