Endocrinology & Metabolic Syndrome
Open Access

Janez A

Publications

• Review Article
  Potential New Pharmacological Approaches in Obese Women with Polycystic Ovary Syndrome
  Author(s): Janez A and Jensterle MJanez A and Jensterle M
  
  Obesity is frequently present in women with polycystic ovary syndrome (PCOS). It aggravates the adverse features of the syndrome and increases the metabolic risk in this population. Weight management by lifestyle intervention often remains unsatisfactory and non-sustainable. In the present mini review we revised limited studies addressing the potential use of agents mediating through GLP-1 in PCOS. We reported that short-term intervention with long acting GLP-1 analogue liraglutide is associated with consistent BMI decrease in treatment naive obese women with PCOS and in those who had been previously poor responders to metformin and lifestyle modification. Metformin, a well-established therapy used in PCOS with high metabolic risk, was recognized as a mechanistically well-suited combination with liraglutide. Short-term intervention with liraglutide also improved eating behavior in obe.. View More»
  DOI: 10.4172/2161-1017.1000261

  Abstract PDF

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