Journal of Blood Disorders & Transfusion

Iolanda Santimone

Publications

• Review Article
  Sticky Platelet Syndrome and the Role of Glycoprotein Receptors: A Review of Literature
  Author(s): Iolanda Santimone and Donato GemmatiIolanda Santimone and Donato Gemmati
  
  Thrombotic events are mainly caused by defects in circulating plasma proteins and platelets. Normally, the formers include hereditary clotting defects [e.g. deficiencies in protein-S (PS), in protein-C (PC), in antithrombin (AT) genes, or factor V Leiden, and Prothrombin (PT) G20210A substitution] and autoimmune diseases [(anti-phospholipid-antibodies syndrome (APA)]. Although these conditions are well-described in literature, prothrombotic platelet disorders are less well understood. The sticky platelet syndrome (SPS) is a congenital, autosomal dominant disorder, associated with both arterial and venous thromboembolic events. In pregnant women, complications such as fetal growth retardation and fetal loss have been reported. It is characterized by in vitro platelets hyperaggregability (platelet-rich plasma; PRP) triggered by different agonists responsible for its subclassifcation: ad.. View More»
  DOI: 10.4172/2155-9864.1000173

  Abstract PDF