Journal of Blood Disorders & Transfusion

Journal of Blood Disorders & Transfusion
Open Access

ISSN: 2155-9864

+44 2038689735

Donato Gemmati

Donato Gemmati
Haematology Unit-Centre of Haemostasis & Thrombosis,
I-44100, Ferrara

  • Review Article
    Sticky Platelet Syndrome and the Role of Glycoprotein Receptors: A Review of Literature
    Author(s): Iolanda Santimone and Donato GemmatiIolanda Santimone and Donato Gemmati

    Thrombotic events are mainly caused by defects in circulating plasma proteins and platelets. Normally, the formers include hereditary clotting defects [e.g. deficiencies in protein-S (PS), in protein-C (PC), in antithrombin (AT) genes, or factor V Leiden, and Prothrombin (PT) G20210A substitution] and autoimmune diseases [(anti-phospholipid-antibodies syndrome (APA)]. Although these conditions are well-described in literature, prothrombotic platelet disorders are less well understood. The sticky platelet syndrome (SPS) is a congenital, autosomal dominant disorder, associated with both arterial and venous thromboembolic events. In pregnant women, complications such as fetal growth retardation and fetal loss have been reported. It is characterized by in vitro platelets hyperaggregability (platelet-rich plasma; PRP) triggered by different agonists responsible for its subclassifcation: ad.. Read More»
    DOI: 10.4172/2155-9864.1000173

    Abstract PDF

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