Biochemistry & Pharmacology: Open Access

Biochemistry & Pharmacology: Open Access
Open Access

ISSN: 2167-0501

+44-77-2385-9429

Hui Wang

Hui Wang

China

Publications
  • Research Article
    Oral Intake of Krill Oil Has Prophylactic and Potential Therapeutic Effects on Alcoholic Fatty Liver in Rats Fed With High-Fat Diet
    Author(s): Hong-ling Wang, Mao-wu Guo, Qin Liao, Hui Wang, Wei-juan Zhang, Yun-xia Sun, Li Han, Tomoko Tsuji and Conglin ZuoHong-ling Wang, Mao-wu Guo, Qin Liao, Hui Wang, Wei-juan Zhang, Yun-xia Sun, Li Han, Tomoko Tsuji and Conglin Zuo

    Aim: The objective of this study was to evaluate the prophylactic and therapeutic effects of Krill Oil on alcohol induced fatty liver in rats on high-fat diet. Methods: Male Sprague-Dawley rats (7-8 weeks old) were gavaged with alcohol and fed with high-fat diet for six weeks to induce alcoholic fatty liver. The concentration of the alcohol formulation had a step increase to have the animal acclimated, with 8% in week 1, 12% in week 2, 20% in week 3, 30% in week 4, and 40% alcohol in the following weeks, and the dose volume was 10 ml/kg. Krill oil at daily oral dose of 10, 100 or 1000 mg/kg was given to animals along with alcohol gavage in a prophylactic experiment, or at 100 and 1000 mg/kg after six weeks of alcohol gavage in a therapeutic experiment, with or without continuing oral gavage of alcohol for four weeks. Blood samples and liver tissues were ta.. View More»
    DOI: 10.4172/2167-0501.1000189

    Abstract PDF

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