Biochemistry & Pharmacology: Open Access
Open Access
ISSN: 2167-0501
+44-20-4587-4809
ISSN: 2167-0501
+44-20-4587-4809
Hong-ling Wang
Beijing Key Laboratory of Bio-products Safety Assessment, JOINN Laboratories,
Beijing
China
Research Article
Oral Intake of Krill Oil Has Prophylactic and Potential Therapeutic Effects on Alcoholic Fatty Liver in Rats Fed With High-Fat Diet
Author(s): Hong-ling Wang, Mao-wu Guo, Qin Liao, Hui Wang, Wei-juan Zhang, Yun-xia Sun, Li Han, Tomoko Tsuji and Conglin ZuoHong-ling Wang, Mao-wu Guo, Qin Liao, Hui Wang, Wei-juan Zhang, Yun-xia Sun, Li Han, Tomoko Tsuji and Conglin Zuo
Aim: The objective of this study was to evaluate the prophylactic and therapeutic effects of Krill Oil on alcohol induced fatty liver in rats on high-fat diet. Methods: Male Sprague-Dawley rats (7-8 weeks old) were gavaged with alcohol and fed with high-fat diet for six weeks to induce alcoholic fatty liver. The concentration of the alcohol formulation had a step increase to have the animal acclimated, with 8% in week 1, 12% in week 2, 20% in week 3, 30% in week 4, and 40% alcohol in the following weeks, and the dose volume was 10 ml/kg. Krill oil at daily oral dose of 10, 100 or 1000 mg/kg was given to animals along with alcohol gavage in a prophylactic experiment, or at 100 and 1000 mg/kg after six weeks of alcohol gavage in a therapeutic experiment, with or without continuing oral gavage of alcohol for four weeks. Blood samples and liver tissues were ta.. View More»
DOI:
10.4172/2167-0501.1000189