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Biochemistry & Pharmacology: Open Access

Biochemistry & Pharmacology: Open Access
Open Access

ISSN: 2167-0501

+44-20-4587-4809

Hitoshi Mineo

Hitoshi Mineo

Eniwa, Hokkaido 061-1449
Japan

Publications
  • Research Article
    Relationship between Partition Coefficients of Carboxylic Acids and Changes in Osmotic Resistance in Rat Erythrocytes In vitro
    Author(s): Hitoshi MineoHitoshi Mineo

    We examined monocarboxylic and dicarboxylic acids and their partition coefficients for osmotic fragility (OF) in isolated red blood cells (RBCs) in rats. The dense packed RBC was incubated in a phosphate–NaCl buffer solution containing each carboxylic acid at 0 to 100 mM at 37ºC for 1 h. The RBC suspensions were transferred into the OF test tubes containing NaCl from 0.2 to 0.9%. The hemoglobin concentration was determined and NaCl concentration inducing 50% hemolysis was calculated as OF value. The OF in RBCs was dose-dependently increased by exposure to some of monocarboxylic acids possessing certain length of hydrocarbons with more than 4 carbons. A positive and statistically significant correlation was obtained between the partition coefficients and the degree of change in OF for monocarboxylic acids. Dicarboxylic acids corresponded with the monocarboxylic acids had eit.. View More»
    DOI: 10.4172/2167-0501.1000236

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