Endocrinology & Metabolic Syndrome
Open Access
ISSN: 2161-1017
+44 1478 350008
ISSN: 2161-1017
+44 1478 350008
Heming Olsen-Bergem
Institute for Clinical Dentistry,
Box 1109 Blindern, N-0317 Oslo
Norway
Research Article
Temporomandibular Joint Pain is Negatively Correlated to TNF Alpha and Osteoprotegrin Content in Synovial Fluid in Patients with Juvenile Idiopathic Arthritis
Author(s): Heming Olsen-Bergem, Tore Bjørnland and Janne E ReselandHeming Olsen-Bergem, Tore Bjørnland and Janne E Reseland
Objective: Temporomandibular joint (TMJ) involvement occurs in up to 80% of children with juvenile idiopathic arthritis (JIA). Little is known with regard to the complexity of the protein profile in synovial fluid (SF) from JIA arthritis during growth as compared to both JIA and rheumatoid arthritis (RA) of adults.
Design: Synovial fluid was collected from 54 joints/30 patients with TMJ arthritis (JIA 35 joints/20 patients, JIA adults 9 joints/5 patients, RA 10 joints/5 patients). Three cytokines and seven bone markers were quantified using Luminex multiplex assays and compared to demographic and clinical data of function and pain.
Results: Pain (spontaneous and upon palpation) and duration of pain were all negatively correlated with the TMJ SF content of tumor necrosis factor (TNF)-α. The level of Adrenocort.. View More»
DOI:
10.4172/2161-1017.1000145