Anatomy & Physiology: Current Research
Open Access
ISSN: 2161-0940
+44 1300 500008
ISSN: 2161-0940
+44 1300 500008
Hagar A Hashish
Faculty of Medicine,
Egypt
Research Article
Alteration of Glial Fibrillary Acidic Protein Immunoreactivity in Astrocytes of the Cerebellum of Diabetic Rats and Potential Effect of Insulin and Ginger
Author(s): Hagar A HashishHagar A Hashish
Background: Diabetes causes increased oxidative stress and changes in vascular reactivity in the brain. Ginger has a wide range of pharmacological properties including anti-inflammatory, anti-microbial, antioxidant, and antitumour effects. Aim of the work: The purpose of this study was to clarify the effect of induced type I diabetes on the cerebellum of albino rat and whether these changes could be prevented by insulin and ginger. Material and methods: Forty albino rats were divided randomly into 4 groups; control non-diabetic rats; untreated diabetic rats; insulin-treated diabetic rats and combined insulin-ginger treated diabetic rats. After 8 weeks of treatment, animals were sacrificed; cerebellum was dissected, processed and stained with H&E and immunohistochemistry for Glial Fibrillary Acidic Protein (GFAP). Results: Diabetes caused decrease .. View More»
DOI:
10.4172/2161-0940.1000167