Endocrinology & Metabolic Syndrome
Open Access
ISSN: 2161-1017
+44 1478 350008
ISSN: 2161-1017
+44 1478 350008
Gregory C. Gass
Australia
Review Article
Rapid Communication - Effect of Exercise Training on Asymmetric Dimethylarginine Concentration in Women Aged 65-74 years with Type 2 Diabetes
Author(s): Kevin R Serre, Michael J. Simmonds, Surendran Sabapathy, Clare L. Minahan and Gregory C. GassKevin R Serre, Michael J. Simmonds, Surendran Sabapathy, Clare L. Minahan and Gregory C. Gass
Aims/hypothesis: Basal plasma concentration of asymmetric dimethylarginine (ADMA), an endogenous, competitive inhibitor of nitric oxide synthase, is elevated in patients with type 2 diabetes. ADMA may contribute to the endothelial dysfunction and associated vascular complications observed in individuals with type 2 diabetes. The present study investigated the effect of 12 weeks of supervised walking exercise on plasma ADMA concentration in women aged 65-74 years with type 2 diabetes. Materials and methods: Fourteen women (aged 69 ± 3 yrs) with uncomplicated type 2 diabetes, completed 12 weeks of supervised, moderate-intensity walking at an intensity equivalent to their individual gas-exchange threshold. Blood was sampled for ADMA concentration before and after a 6-week intervention-free control period, and again after 6 and 12 weeks of exercise training. Results: Plasma ADMA conc.. View More»
DOI:
10.4172/2161-1017.S5-001