Biochemistry & Pharmacology: Open Access
Open Access
ISSN: 2167-0501
+44-20-4587-4809
ISSN: 2167-0501
+44-20-4587-4809
Gornowicz A
Kilinskiego 1, 15-089 Bialystok
Poland
Short Communication
The Influence of Anti-MUC1 with Berenil Complex of Platinum(II) on Concentration of Apoptotic Markers in Human Skin Fibroblasts
Author(s): Gornowicz A, Bielawska A, Gabryel-Porowska H and Bielawski KGornowicz A, Bielawska A, Gabryel-Porowska H and Bielawski K
MUC1 mucin is a type I transmembrane glycoprotein expressed at the apical border of healthy epithelia that line the respiratory, reproductive and gastrointestinal tracts and is overexpressed in various cancer cells. The goal of the study was to check the effect of berenil complex of Platinum(II) applied together with anti-MUC1 antibody on induction of programmed cell death in human skin fibroblasts. The influence of novel platinum(II) complex used with anti-MUC1 on the concentration of selected markers of apoptosis such as p53, Bax, cytochrome c, caspase-8, -9 and caspase-3 was determined using the ELISA technique. The results from combined treatment were compared with those obtained using monotherapy and combined treatment with cisplatin and anti-MUC1. In our study we observed that combined treatment of Pt12 with anti-MUC1 had no influence on the induction of programmed cell death in.. View More»
DOI:
10.4172/2167-0501.1000198