Endocrinology & Metabolic Syndrome
Open Access
ISSN: 2161-1017
+44 1478 350008
ISSN: 2161-1017
+44 1478 350008
Gisele Facholi Bomfim
1120 15th St Physiology CA- 3101 Augusta, GA 30912
Tanzania
Review Article
The Toll way to hypertension: role of the innate immune response
Author(s): Gisele Facholi Bomfim, Theodora Szasz, Maria Helena C. Carvalho and R. Clinton WebbGisele Facholi Bomfim, Theodora Szasz, Maria Helena C. Carvalho and R. Clinton Webb
The involvement of pro-inflammatory processes in cardiovascular disease such as hypertension is a well accepted
concept. Human hypertension is associated with increased levels of circulating cytokines and their participation in the
associated target organ damage has clearly been demonstrated. Recent evidence suggests that at least in animal
models of hypertension, components of the adaptive immune system such as T cells are activated and infiltrate target
organs, promoting inflammation and thus participating in the maintenance of increased blood pressure. However
there is a paucity of information on the role of the innate immune response in hypertension. Moreover, the identity
of the original stimuli responsible for the immune system activation as well as the chronology of these events during
hypertension pathogenesis is unknown. The current paradigm is that the immune system is a.. View More»
DOI:
10.4172/2161-1017.1000117