Biochemistry & Pharmacology: Open Access

Biochemistry & Pharmacology: Open Access
Open Access

ISSN: 2167-0501


Gino Giannaccini

  • Review Article
    Sulfur Metabolism and Sulfur-Containing Amino Acids: I- Molecular Effectors
    Author(s): Lionella Palego, Laura Betti and Gino GiannacciniLionella Palego, Laura Betti and Gino Giannaccini

    The biology of the macro-element sulfur (S) is attracting an ever growing attention concerning cell physiology and human health. Sulfur metabolism works at the interplay between genetics and epigenetic as well as in the maintain of cell redox homeostasis. Indeed, unbalanced levels of S compounds in the body are actually under investigation as vulnerability factors and/or indicators of impaired cell oxidation state in a variety of human diseases. The purpose of this article is to overview some main S metabolic pathways in humans and their relevance in cell physiology and pathology. Since S is an essential nutrient for life, we first present its distribution and significance in the biosphere, focusing then on S metabolic fluxes which encompass S-containing amino acids (S-AAs), as well as sulfoconjugation, the synthesis and release of H2S together the formation of iron-sulfur cluster pro.. View More»
    DOI: 10.4172/2167-0501.1000158

    Abstract PDF

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