Biochemistry & Pharmacology: Open Access
Open Access
ISSN: 2167-0501
+44-20-4587-4809
ISSN: 2167-0501
+44-20-4587-4809
García I
Spain
Research Article
State of Art: Review of Theoretical Study of GSK-3β and a New Neural Networks QSAR Studies for the Design of New Inhibitors Using 2D-Descriptors
Author(s): García I and Prado-Prado FGarcía I and Prado-Prado F
Alzheimer's disease (AD) is characterized by several pathologies, as this disease involves neuropathological lesions in the brain. Indeed, a wealth of evidence suggests that β-amyloid is central to the pathophysiology of AD and is likely to play an early role in this intractable neurodegenerative disorder. AD is the most prevalent form of dementia, and current indications show that twenty-nine million people live with AD worldwide, a figure expected to rise exponentially over the coming decades. Clearly, blocking disease progression or, in the best-case scenario, preventing AD altogether would be of benefit in both social and economic terms. However, current AD therapies are merely palliative and only temporarily slow cognitive decline, and treatments that address the underlying pathologic mechanisms of AD are completely lacking. While familial AD (FAD) is caused by autosomal.. View More»
DOI:
10.4172/2167-0501.1000170