Endocrinology & Metabolic Syndrome

Endocrinology & Metabolic Syndrome
Open Access

ISSN: 2161-1017

+44 20 3868 9735

Frankel AH

Frankel AH
Imperial College Kidney and Transplant Institute, Hammersmith Hospital, Imperial College London,
United Kingdom

  • Review Article
    Effect of Insulin Resistance in Chronic Kidney Disease
    Author(s): Frankel AH and Kazempour-Ardebili SFrankel AH and Kazempour-Ardebili S

    Insulin resistance accompanies many well-established cardiovascular risk factors, such as obesity, hypertension, dyslipidaemia and type 2 diabetes. Since cardiovascular disease (CVD) is the leading cause of death in patients with end stage renal disease (ESRD), insulin resistance is thought to play a role in the morbidity and mortality associated with ESRD. This paper reviews the available information on insulin resistance in patients with impaired kidney function as well as those on renal replacement therapy in the form of maintenance hemodialysis. Potential mechanisms for the dynamic changes in insulin resistance, which occur through the different stages of kidney disease, are also discussed. We hypothesize that stabilizing insulin sensitivity may have a positive effect on improving outcome in ESRD subjects. .. Read More»
    DOI: 10.4172/2161-1017.1000255

    Abstract PDF

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