Biochemistry & Pharmacology: Open Access
Open Access
ISSN: 2167-0501
+44-20-4587-4809
ISSN: 2167-0501
+44-20-4587-4809
Francesco Scaglione
Professor, Department of Medical Biotechnology and Translational Medicine,
Via Vanvitelli 32, 20129- Milan
Italy
Research Article
Activity of Panax ginseng C.A. Meyer on Energy Production in Mammals
Author(s): Marilou Pannacci, Valeria Lucini, Silvana Dugnani, Rocco Ciracì, Andrea Zangara and Francesco ScaglioneMarilou Pannacci, Valeria Lucini, Silvana Dugnani, Rocco Ciracì, Andrea Zangara and Francesco Scaglione
Panax ginseng is traditionally used for enhancement of physical capacities, especially in the condition of severe fatigue. To evaluate the ability of ginseng in enhancing performance, we focused on the gene expression of AMPK, PGC-1α and SIRT1 genes, involved in energy balance. Gene expression was evaluated in C2C12 myotubes, using P. ginseng C.A. Meyer standardized extract G115, at various concentrations (10-50-100-200 mg/L) for 24, 48, 72 h of incubation. G115 increased significantly the expression of AMPK and PGC-1α in the dose and time-dependent manner: at the concentration of 10 mg/L there is an increase after 72 h of incubation while at 50 mg/L after 48 h and maintained for 72 h. G115 increased expression of SIRT1 at 10 mg/L after 24 h, while at 50 mg/L after 24 and 48 h. The treatment enhanced cellular ATP levels and O2 consumption only at 50 mg/L. We investigated A.. View More»
DOI:
10.4172/2167-0501.1000221