Biochemistry & Pharmacology: Open Access
Open Access
ISSN: 2167-0501
+44-20-4587-4809
ISSN: 2167-0501
+44-20-4587-4809
El-Baky AEA
Egypt
Review Article
NOS Expression in Oxidative Stress, Neurodegeneration and Male Infertility Induced by the Abuse of Tramadol
Author(s): El-Baky AEA and Hafez MMEl-Baky AEA and Hafez MM
Tramadol is widely used as a pain reliever; stimulant and it may delay ejaculation. But chronic tramadol users have adverse side effects. Aim: To clarify the worst effect of tramadol hydrochloride on male fertility and its role in neurodegeneration disorders due to oxidative stress in spite of indeed its use as ejaculation delaying. Materials and methods: This experimental study was performed upon 30 adult wistar rats. They were purchased from the National Research Centre Cairo, Egypt. These rats were divided into three groups (n=10), Group I, rats received vehicle and served as normal control. Group II, rats received low dose of tramadol (20 mg/Kg body weight/ day). Group III, rats received high dose of tramadol (50 mg/Kg body weight/day) for 12 weeks. Results: The results illustrated that tramadol in both low and high doses ingestion lead to weight loss, elevated Nitric Oxide Syntha.. View More»
DOI:
10.4172/2167-0501.1000223