Gynecology & Obstetrics
Open Access
ISSN: 2161-0932
ISSN: 2161-0932
David Wai CHAN
David Wai CHAN
Assistant Professor
Department of Obstetrics & Gynaecology
L747 Laboratory Block, LKS Faculty of Medicine,
21 Sassoon Road, Pokfulam, Hong Kong, SAR, PR. China
Dr. Chan received his PhD from Monash University, Australia in 2002. He completed postgraduate training in molecular oncology in Peter MacCallum Cancer Institute at Melbourne and in Department of Pathology, the University of Hong Kong from 2002 to 2005. He currently works in Department of Obs. & Gyn, the University of Hong Kong as a Research Assistant Professor. His main research interests include functional characterization of tumor suppressors and oncogenes and delineation of the related cellular signaling pathways which contribute to the tumorigenesis of gynaecological malignancies. He has particular interest in ERK, Hedgehog and Wnt/-catenin signaling pathways as well as related miRNAs in the development of chemo-resistance and metastasis in ovarian cancers.
1. Functional characterization of tumor suppressors and oncogenes and delineation of the related cellular signaling pathways such as AMPK, ERK, Hedgehog and Wnt/ï¢-catenin signaling pathways which contribute to the tumorigenesis of gynaecological malignancies.
2. To examine the role of miRNAs in the development of chemoresistance and metastasis in ovarian cancer.
3. To understand the underlying molecular mechanisms associated with cancer cell metabolism and tumor microenvironment in ovarian cancer.