Endocrinology & Metabolic Syndrome
Open Access
ISSN: 2161-1017
ISSN: 2161-1017
Cossio I
Colombia
Review Article
The Triumvirate of Adiposopathy: A Literature Review and Proposal of the Claros Pathophysiological Model
Author(s): Rosero RJ, Polanco JP, Jaramillo A, Gómez AM, Cossio I, Cortés D, Uribe A, Palacio JI and Geloneze BRosero RJ, Polanco JP, Jaramillo A, Gómez AM, Cossio I, Cortés D, Uribe A, Palacio JI and Geloneze B
Obesity is currently considered as the 21st century epidemic. The accelerated increase in prevalence and mortality due to cardiovascular diseases establishes a historical precedent as a global public health problem. The increased incidence of obesity and obesity-associated chronic diseases (coronary heart disease, cancer, diabetes), together with the frequent finding of these conditions in the clinic, urgently call for studies aiming to identify possible pathophysiologic connections among these conditions.
Obesity is often seen only as an imbalance between caloric intake and energy expenditure. On the other hand, numerous neuroendocrine factors are responsible for the regulation of energy metabolism. In addition, body metabolism is also affected by the autocrine, paracrine, and endocrine activity of organokines. Thus, the understanding signaling pathways, action and regulati.. View More»
DOI:
10.4172/2161-1017.1000293