Gynecology & Obstetrics
Open Access
ISSN: 2161-0932
ISSN: 2161-0932
Begoña Martinez De Tejada
Geneva University Hospitals and Faculty of Medicine,
30 Boulevard de la Cluse, 1211 Geneva 14/Switzerland
Switzerland
Case Report
Maternal Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-Like Episodes Syndrome and Neonatal Magnesium Toxicity: A Case Report
Author(s): Bénédicte Le Tinier, Kuntheavy Ing Lorenzini, Arnault Joal and Begoña Martinez De TejadaBénédicte Le Tinier, Kuntheavy Ing Lorenzini, Arnault Joal and Begoña Martinez De Tejada
Introduction: Mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome is a progressive disorder associated with neurologic, cardiac, neuromuscular, hepatic, metabolic and gastrointestinal dysfunction, including potential anesthetic and obstetrical complications. Increased susceptibility to drugs in patient with MELAS syndrome can be due to drug-induced mitochondrial toxicity and/or decreased elimination. We present here a case of severe neonatal magnesium sulfate toxicity in the context of MELAS syndrome.
Case presentation: A 43-year-old, gravida 5, para-5 (4 prior vaginal deliveries and the current cesarean section) woman with asymptomatic MELAS syndrome (carrier of the genetic variant NC_012920.1: m3243A>G in 20% of the mitochondrial DNA) was given intravenous magnesium sulfate for preeclampsia shortly.. View More»
DOI:
10.4172/2161-0932.1000429