Biochemistry & Pharmacology: Open Access
Open Access
ISSN: 2167-0501
+44-20-4587-4809
ISSN: 2167-0501
+44-20-4587-4809
Artem V Domashevskiy
John Jay College of Criminal Justice,
524 West 59th Street, New York, NY 10019
Tanzania
Review Article
Insights into the Molecular Antiviral Mechanism of Pokeweed Protein from Phytolacca americana
Author(s): Valentina R Aitbakieva and Artem V DomashevskiyValentina R Aitbakieva and Artem V Domashevskiy
Agriculture is an indispensable part of every person’s life, ensuring that nutritious and inexpensive food is readily available. As any other organisms, plants are subject to numerous parasitic infections. Biological evolution has allowed plants to produce a variety of toxic compounds to deal with their pathogens. American pokeweed plant (Phytolacca americana) manufactures pokeweed antiviral protein, a ribosome inactivating protein that disrupts protein synthesis and lowers infectivity of many plant and animal viruses. The intricate mechanism of PAP antiviral activity entails a delicate coordination and interplay of several factors, allowing the plant to battle its invaders. Here, we examine the molecular mechanism of this plant peptide, and describe a molecular model of pokeweed’s antiviral activity.
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DOI:
10.4172/2167-0501.1000210