Gynecology & Obstetrics
Open Access
ISSN: 2161-0932
ISSN: 2161-0932
Andy Petroianu
School of Medicine of the Federal University of Minas Gerais,
Belo Horizonte
Brazil
Research Article
Estrous Cycle, Fertility and Fetal Development in Rats with Hyperbilirubinemia
Author(s): Vivian Resende, Luiz Ronaldo Alberti and Andy PetroianuVivian Resende, Luiz Ronaldo Alberti and Andy Petroianu
Objective: Decreasing in reproductive capacity has been observed in jaundiced female rats. The animals with hyperbilirubinemia present early sexual maturation, late ovulation, reduced number of corpora lutea and precocious vaginal opening. The interaction with toxic agents leads to abnormal development of the embryos. The objective is to investigate the influence of jaundice on estrous cycle, fertility, ovaries and fetus development.
Methods: 66 female rats were divided into two groups (n=33): group 1 - ligature of the biliopancreatic duct, group 2 - sham operation. These animals were paired with males. Vaginal smears were collected daily to verify pregnancy and the gestational period. The morphologic aspect of the ovaries and the corpus luteum were studied. The morphology of the fetuses were assessed. Serum bilirubins were recorded. 32 rats of.. View More»
DOI:
10.4172/2161-0932.1000426