Endocrinology & Metabolic Syndrome
Open Access
ISSN: 2161-1017
ISSN: 2161-1017
Amit Gupta
India
Research Article
Efficacy of Maximum and Optimum Doses of Hydroxychloroquine Added to Patients with Poorly Controlled Type 2 Diabetes on Stable Insulin Therapy along with Glimepiride And Metformin: Association of High-Sensitive C-Reactive Protein (Hs-CRP) and Glycosy
Author(s): Arjun Baidya, Hridish Narayan Chakravarti, Ravi Kant Saraogi, Amit Gupta, Rishad Ahmed, Abhishek Banerjee6 and Satpathy SC
Arjun Baidya, Hridish Narayan Chakravarti, Ravi Kant Saraogi, Amit Gupta, Rishad Ahmed, Abhishek Banerjee6 and Satpathy SC
Aim: To determine the efficacy of maximum and optimum dosages of hydroxychloroquine (400 and 200 mg once daily) treatment combined with insulin along with metformin and Glimepiride in Type 2 diabetes patients who are poorly controlled and relationship to be evaluate between high-sensitive C-reactive protein (hs-CRP) and glycosylated haemoglobin (HbA1c) levels in such patients.
Methods: In a multicentre,open-labelled comparative observational study, randomised 240 patients [mean age 56.44 years and mean body mass index (BMI) 33.20 kg/m2, mean glycosylated haemoglobin (HbA1C) 8.58% ; mean duration of diabetes 13.7 years] with type 2 diabetes who were poorly controlled with a high stable insulin dose (≥ 30 Units/day for ≥ 30 days), glimepiride (2 mg/day) and metformin (1000 mg/day) were randomly allocated to either hydroxychloroquine 200 or .. View More»
DOI:
10.4172/2161-1017.1000283