Biochemistry & Pharmacology: Open Access

Biochemistry & Pharmacology: Open Access
Open Access

ISSN: 2167-0501


Amar B Singh

Amar B Singh
Department of Biochemistry and Molecular Biology Member, Fred and Pamela Buffett Cancer Center,
985870, Omaha, NE 68198-5870

  • Review Article
    Cancer Stem Cell and Gastrointestinal Cancer: Current Status, Targeted Therapy and Future Implications
    Author(s): Rizwan Ahmad, Punita Dhawan and Amar B SinghRizwan Ahmad, Punita Dhawan and Amar B Singh

    The cancer stem cells (CSCs) are biologically distinct subset of rare cancer cells with inherent ability of self-renewal, de-differentiation, and capacity to initiate and maintain malignant tumor growth. Studies have further reported that CSCs prime cancer recurrence and therapy resistance. Therefore, targeting CSCs to inhibit cancer progression has become an attractive anti-cancer therapeutical strategy. Recent technical advances have provided a greater appreciation of the multistep nature of the oncogenesis and also clarified that CSC concept is not universally applicable. Irrespective, the role of the CSCs in gastrointestinal (GI) cancers, responsible for the most cancer-associated death, has been widely accepted and appreciated. However, despite the tremendous progress made in the last decade in developing markers to identify CSCs, and assays to assess.. View More»
    DOI: 10.4172/2167-0501.1000202

    Abstract PDF

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