Endocrinology & Metabolic Syndrome
Open Access

Ahmed RG

Publications

• Review Article
  Maternal Iodine Deficiency and Brain Disorders
  Author(s): Ahmed RGAhmed RG
  
  Thyroid Hormones (THs) play an essential role in development and hormone deficiency during critical phases in fetal life may lead to severe and permanent brain damage. Maternal iodine deficiency is considered the most common cause of fetal TH deficiency, but the problem may also arise in the fetus/neonates. Due to defects in fetal thyroid gland development or hormone synthesis, clinical symptoms at birth are often mild as a result of compensatory maternal TH supply. A shortage of THs starting at the early stages of pregnancy results in neurological deficits that cannot be rescued by exogenous TH addition at later stages. Neonates are more sensitive than adults to the effects of iodine deficiency. Thus, these disturbances may lead to abnormalities in the neuronal network and may result in mental retardation and other neurological defects, including impaired motor skills and visual proc.. View More»
  DOI: 10.4172/2161-1017.1000223

  Abstract PDF

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