Gynecology & Obstetrics
Open Access
ISSN: 2161-0932
ISSN: 2161-0932
Adel A Elsayed
Egypt
Research Article
Oral Hypoglycemic as Attractive Alternative to Insulin for the Management of Diabetes Mellitus during Pregnancy
Author(s): Magdy A Mohamed, Allam M Abdelmonem, Mostafa A Abdellah and Adel A ElsayedMagdy A Mohamed, Allam M Abdelmonem, Mostafa A Abdellah and Adel A Elsayed
Objective: To study the efficacy and safety of glibenclamide/metformin combination as a treatment option for pregnant women with either gestational diabetes or type-2 diabetes mellitus compared to conventional insulin therapy.
Methods: Eighty-four pregnant women with singleton pregnancies (65 women with gestational diabetes & 19 with type-2 diabetes mellitus) were included. They were randomly allocated to receive either glibenclamide/metformin combination or insulin. The primary end point was the achievement of the desired level of glycemic control. The presence or absence of maternal, fetal and/or neonatal complications was measured as secondary end points.
Results: There were no differences between the oral hypoglycemic-treated group and insulin-treated group as regard the mean blood glucose levels. It was 125.64 &.. View More»
DOI:
10.4172/2161-0932.1000193