Journal of Genetic Syndromes & Gene Therapy
Open Access

Abstract

Transmission of Bacteria during Cystic Fibrosis Educational Programs

Niels Nørskov-Lauritsen and Peter Oluf Schiøtz

CF is a progressive, lethal disease characterized by mucous build-up in the airways and a continuous annual deterioration of lung function. The host inflammatory response is considered a central pathological feature and constitutes an important target for non-steroidal anti-inflammatory drug therapy. Airway obstruction and bacterial colonization may cause inflammation, or it may be attributable to dysfunction of the cystic fibrosis transmembrane conductance regulator. Educational programs for this group of patients increase the compliance and quality-of-life, but cystic fibrosis patients have been recommended to abstain from attendance for concerns of microbial cross infection. When guidelines for optimal hand and respiratory hygiene and cough etiquette are observed in professionally supervised CF educational programs, an increased risk of bacterial transmission has not been documented. A recommendation to avoid indoor educational events with fellow CF patients must be weighed against the benefits of educational and rehabilitation programs. Further investigations are required to clarify the relative contribution of microbiological and genetic factors to the progression of CF lung disease.